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Regeneration is a 1915 American silent biographical crime drama co-written and directed by Raoul Walsh. The film, which was the first full-length feature film directed by Walsh, stars Rockliffe Fellowes and Anna Q. Nilsson and was adapted for the screen by Carl Harbaugh and Walsh from the memoir My Mamie Rose, by Owen Frawley Kildare and the adapted play by Kildare and Walter C. Hackett.

Cited as one of the first full-length gangster films, Regeneration tells the story of a poor orphan who rises to control the mob until he meets a woman for whom he wants to change.

Regeneration was previously thought to be lost but was rediscovered in the 1970s. A copy of the film is preserved and held by the Museum of Modern Art Department of Film and the Film Preservation Associates.

In 2000, Regeneration was selected for preservation in the United States National Film Registry by the Library of Congress as being “culturally, historically or aesthetically significant”.

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